John R Moffett Selected Research

N-acetylaspartate (N-acetyl aspartate)

1/2017	Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease.
12/2013	N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation.
9/2013	N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.
1/2013	Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells.
6/2010	Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS.
6/2010	Riluzole decreases synthesis of N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.
1/2010	Metabolic acetate therapy for the treatment of traumatic brain injury.
9/2009	Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells.
8/2008	Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.
10/2006	Aspartoacylase is a regulated nuclear-cytoplasmic enzyme.

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John R Moffett Research Topics

Disease

10	Canavan Disease (Leukodystrophy, Spongiform) 01/2022 - 04/2005
8	Neoplasms (Cancer) 01/2020 - 12/2006
5	Neuroblastoma 06/2010 - 04/2005
4	Inflammation (Inflammations) 01/2020 - 09/2002
4	Carcinogenesis 01/2020 - 09/2013
4	Brain Injuries (Brain Injury) 12/2013 - 09/2002
2	Infections 01/2020 - 01/2016
2	Organophosphate Poisoning 12/2017 - 03/2016
2	Pain (Aches) 01/2017 - 09/2012
2	Traumatic Brain Injuries (Traumatic Brain Injury) 12/2013 - 01/2010
2	Schizophrenia (Dementia Praecox) 06/2012 - 08/2008
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2006 - 10/2005
2	Ischemia 01/2003 - 09/2002
2	Infarction (Infarctions) 01/2003 - 09/2002
1	Status Epilepticus (Complex Partial Status Epilepticus) 12/2017
1	Body Weight (Weight, Body) 07/2017
1	Bone Neoplasms (Bone Cancer) 01/2017
1	Demyelinating Diseases (Demyelinating Disease) 12/2016
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2016
1	Multiple Sclerosis 12/2016
1	Poisoning 02/2016
1	Glioma (Gliomas) 09/2013
1	Oligodendroglioma 01/2013
1	Neuralgia (Stump Neuralgia) 09/2012
1	Psychotic Disorders (Schizoaffective Disorder) 06/2012
1	Tremor (Tremors) 06/2010
1	Temporal Lobe Epilepsy 05/2007
1	Nervous System Diseases (Neurological Disorders) 05/2007

Drug/Important Bio-Agent (IBA)

13	N-acetylaspartate (N-acetyl aspartate)IBA 01/2017 - 04/2005
12	Acetates (Acetic Acid Esters)FDA Link 01/2020 - 04/2005
9	EnzymesIBA 01/2017 - 10/2005
8	aspartoacylaseIBA 01/2022 - 10/2005
7	isospaglumic acid (NAAGA)IBA 09/2013 - 04/2003
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2013
4	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2020 - 06/2010
4	Glutamic Acid (Glutamate)FDA Link 01/2017 - 08/2008
3	Tryptophan (L-Tryptophan)FDA Link 01/2020 - 01/2016
3	LipidsIBA 12/2013 - 01/2006
2	NexusIBA 01/2020 - 01/2020
2	NAD (NADH)IBA 01/2020 - 01/2016
2	KynurenineIBA 01/2020 - 01/2016
2	Formaldehyde (Formol)FDA Link 01/2017 - 09/2012
2	Peptides (Polypeptides)IBA 12/2016 - 09/2012
2	CytokinesIBA 01/2016 - 09/2002
2	Adenosine Triphosphate (ATP)IBA 12/2013 - 01/2010
2	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA 09/2012 - 06/2012
2	Aspartic Acid (Aspartate)FDA Link 10/2005 - 04/2005
2	NF-kappa B (NF-kB)IBA 01/2003 - 09/2002
1	AntibodiesIBA 01/2020
1	Quinolinic AcidIBA 01/2020
1	Acyl Coenzyme A (Acyl CoA)IBA 01/2020
1	Ligases (Synthetase)IBA 01/2020
1	Cholinergic Agents (Cholinergics)IBA 12/2017
1	Isoflurane FDA LinkGeneric 12/2017
1	Pharmaceutical PreparationsIBA 07/2017
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2017
1	Analgesics (Analgesic Drugs)IBA 01/2017
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2017
1	Therapeutic UsesIBA 12/2016
1	Free RadicalsIBA 12/2016
1	AntioxidantsIBA 12/2016
1	MelatoninIBA 12/2016
1	nasIBA 12/2016
1	N-acetylserotoninIBA 12/2016
1	Atropine FDA LinkGeneric 03/2016
1	pralidoxime (Protopam Chloride)FDA Link 03/2016
1	Obidoxime Chloride (Obidoxime)IBA 03/2016
1	OximesIBA 03/2016
1	CarbonIBA 03/2016
1	Paraoxon (E600)IBA 03/2016
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2016
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2016
1	AlbuminsIBA 01/2016
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2016
1	Essential Amino AcidsIBA 01/2016
1	Triglycerides (Triacylglycerol)IBA 01/2013
1	Acetate-CoA Ligase (Acetyl CoA Synthetase)IBA 01/2013
1	ChromatinIBA 01/2013
1	Cytostatic AgentsIBA 01/2013
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2013
1	Histones (Histone)IBA 01/2013
1	ZJ43IBA 09/2012
1	metabotropic glutamate receptor 3 (mGluR3)IBA 09/2012
1	Dopamine (Intropin)FDA LinkGeneric 06/2012
1	Phencyclidine (Angel Dust)IBA 06/2012
1	N-Methylaspartate (NMDA)IBA 06/2012
1	Glutamate Receptors (Glutamate Receptor)IBA 06/2012
1	Riluzole FDA LinkGeneric 06/2010
1	galactocerebrosideIBA 06/2010
1	Clozapine (Clozaril)FDA LinkGeneric 08/2008
1	Antipsychotic Agents (Antipsychotics)IBA 08/2008
1	Haloperidol (Haldol)FDA LinkGeneric 08/2008
1	Pilocarpine (Ocusert)FDA LinkGeneric 05/2007
1	DipeptidesIBA 05/2007

Therapy/Procedure

5	Therapeutics 03/2016 - 10/2005
1	Spinal Injections 01/2017
1	Intranasal Administration 03/2016
1	Enzyme Therapy 02/2016
1	Analgesia 09/2012
1	Homeopathy 12/2006